Phase transition in lipid monolayers and bilayers
The spatial organization of proteins, lipids, and guest molecules in lipid monolayers, membranes, and thin films ultimately determines their specific interactions and function. The spatial resolution of AFM and LFM (lateral force microscopy) has been used to
investigate mixing in phospholipid monolayers and bilayers formed by Langmuir-Blodgett technique or by vesicle fusion onto mica (Badia, Lafleur, Lennox).
Defects and pore formation in membranes by amphipathic peptides
Organic design and synthesis is being used to access new materials that integrate the structural and functional characteristics of biopolymers with the stability and diversity of synthetic polymers. The principle aim of this research collaboration is to achieve an
in-depth understanding of synthetic macrocycle and oligomer self-assembly within model membranes. In particular, the channel or pore-forming nature of synthetic foldamers and macrocycles are being studied using AFM.